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The correct answer highlights key varietals that are indeed characteristic of the Southern Rhône region. Roussanne, Clairette, and Picpoul are indigenous white grape varieties commonly found in this area and are significant for both their unique flavor profiles and their ability to thrive in the warm Mediterranean climate.

Roussanne offers richness and body to blends, often imparting floral and stone fruit notes, while Clairette provides acidity and freshness, contributing to the overall balance of the wines. Picpoul, known for its zesty citrus characteristics, adds an invigorating quality to blends, making these varietals essential components of the white wines produced in the Southern Rhône.

The other selections include grape varieties that are either not prevalent in the Southern Rhône or are more characteristic of different wine regions. For instance, Chardonnay and Sauvignon Blanc are more closely associated with regions like Burgundy and Bordeaux, while Xarel-lo, Macabeo, and Parellada are traditional grapes found in Spain, particularly in the production of Cava. Vermentino, Riesling, and Chenin Blanc also belong to different wine traditions and regions. Thus, the distinctive selection of Roussanne, Clairette, and Picpoul aligns perfectly with the identity of Southern Rhône white wines.